The Progeria Research Foundation

For the Children ♥ For the Cure

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Vision

Our vision is a world in which every child with Progeria is cured.

Mission

To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.

Vision

Our vision is a world in which every child with Progeria is cured.

Mission

To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.

Progeria is an ultra-rare, fatal, “rapid-aging” disease that afflicts children who, without the FDA-approved treatment lonafarnib, die of heart disease at an average age of 14.5 years. PRF is the only non-profit organization solely dedicated to finding treatments and the cure for Progeria, and is making phenomenal progress toward that goal.

News

Gene Editing: PRF is on the Path to CURE PROGERIA!

After 6 years of intense research, PRF and its partners have created a drug designed to permanently correct the Progeria gene mutation at the DNA level – SO exciting! Click below to meet the gene team and find out more about this transformative program.

PRF’s 12th International Scientific Workshop

Join us at our scientific workshop taking place at the Boston Marriott Cambridge Hotel, from October 29-31, 2025, to hear about the latest breakthroughs in Progeria research.

New clinical trial with the drug Progerinin is officially underway

PRF is thrilled to announce that the first Progerinin clinical trial patient visits are complete!

PRF Co-Founders Drs. Leslie Gordon and Scott Berns speak as thought leaders at CiMUS, Spain

The Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) at the University of Santiago in Spain invited PRF co-founders to share their story at a special event on Rare Disease Day 2025.

The 2024 Donor Impact Snapshot is here!

Take a look at our newly designed 2024 Donor Impact Snapshot and see the incredible progress we’re making thanks to our amazing team, which includes YOU!

Get Involved

Our lonafarnib clinical trials enrolled 107 children from 42 different countries to test this now-FDA-approved treatment. Because of your support, these children and young adults are living longer, healthier lives.