The Progeria Research Foundation

For the Children ♥ For the Cure

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Vision

Our vision is a world in which every child with Progeria is cured.

Mission

To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.

Vision

Our vision is a world in which every child with Progeria is cured.

Mission

To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.

Progeria is an ultra-rare, fatal, “rapid-aging” disease that afflicts children who, without the FDA-approved treatment lonafarnib, die of heart disease at an average age of 14.5 years. PRF is the only non-profit organization solely dedicated to finding treatments and the cure for Progeria, and is making phenomenal progress toward that goal.

News

PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy!

PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy!
This announcement marks a major milestone: PRF has entered into a manufacturing agreement with Forge Biologics to produce SamPro-2, its gene editing therapy in development for children and young adults with Progeria — an essential step toward clinical trials and, ultimately, the cure!

PRF’s 12th International Scientific Workshop

An Overwhelming Success!
Over 120 scientists met in Boston recently for one of the most engaging and exciting scientific workshops we have ever held!

Get PRF’s 2025 Newletter here!

Hot off the press: PRF’s 2025 Newsletter! Get the latest scoop on the Progerinin Clinical Trial, our Path to CURE PROGERIA, and so much more!

New Yorker Features Progeria Gene Editing: PRF is on the Path to CURE PROGERIA!

On August 11, 2025, this top-tier publication featured an in-depth article detailing PRF’s history, accomplishments, and present focus on the Gene Therapy that could bring us closer to curing Progeria. Our extraordinary journey is reaching millions more throughout the world!

New clinical trial with the drug Progerinin is officially underway

PRF is thrilled to announce that the first Progerinin clinical trial patient visits are complete!

Get Involved

Our lonafarnib clinical trials enrolled 107 children from 42 different countries to test this now-FDA-approved treatment. Because of your support, these children and young adults are living longer, healthier lives.